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作者分析70例死后病理证实的多发性硬化症患者,发现有16例于45岁后发病。晚发组与早发对照组相比,其男女比例相同(3∶1),无明确的家族史,晚发组较易漏诊,16例中有3例漏诊,对照组54例中仅有3例。平均病程为8.6±6年(女性为8.1±6年),晚发组较对照组病程短,两组差别显著(P<0.05)。尽管统计学上无意义,晚发组中缓解与复发型和进行性发展型病人有病程短的倾向。与对照组对比,进行性发展型(8例)和急性型(4例)较多见(P<0.05)。两组首发症状和体征无显著差别。以前庭-小脑症状发病者病程演变过程较长。晚发组与早发组新症状、体征出现比率相同,虽然晚发组中运动、感觉和括约肌障碍较多出现,但两组之间无统计学上差别。晚发组中肌萎缩
The authors analyzed 70 patients with pathologically confirmed multiple sclerosis and found that 16 of them developed disease after age 45. There was no clear family history in late-onset group compared with early-onset control group, and there was no clear family history, missed diagnosis in late-onset group, missed diagnosis in 3 of 16 cases and only 3 in 54 cases in control group example. The average duration of disease was 8.6 ± 6 years (8.1 ± 6 years in females), and the duration of disease in the late onset group was shorter than that in the control group (P <0.05). Although statistically insignificant, late-onset patients had a tendency to have shorter duration of disease with patients with relapsing and progressive development. Compared with the control group, progressive developmental type (8 cases) and acute type (4 cases) were more common (P <0.05). There was no significant difference in the first symptom and symptom between the two groups. In the vestibular - cerebellar disease pathogenesis of the evolution process is longer. The rates of appearance of new symptoms and signs in late onset group and early onset group were the same. Although there were more motor, sensory and sphincter disorders in late onset group, there was no statistical difference between the two groups. Late onset group muscle atrophy