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目的回顾谷氨酰胺、癌症及其治疗方面的一些进展，主要是关于谷氨酰胺与肿瘤生长方面的体内与体外、动物和人体的研究结果。对荷瘤宿主在接受放疗和化疗时补充谷氨酰胺的某些益处进行总结。背景谷氨酰胺是体内最丰富的游离氨基酸。而肿瘤组织就象一个“谷氨酰胺网”消耗大量的谷氨酰胺，从而促使机体恶病质的发生。体外研究中，肿瘤细胞的生长依赖于谷氨酰胺的结果使得人们未在临床上给癌症病人补充谷氨酰胺。方法对谷氨酰胺与接受放、化疗荷瘤宿主的关系的研究结果进行归纳和总结。结果大量体内研究表明，补充谷氨酰胺不但不会使肿瘤生长，而且还会通过刺激机体的免疫系统来抑制肿瘤的生长。在机体接受放疗和化疗时，谷氨酰胺可以保护机体并增加化疗对肿瘤的选择性。结论还需要进行前瞻、随机的研究来证明在接受放疗和化疗的病人补充谷氨酰胺的安全性和有效性。
Objectives To review some of the advances in glutamine, cancer, and its treatment, mainly on the in vivo and in vitro, animal, and human studies of glutamine and tumor growth. Some of the benefits of glutamine supplementation in radiation- and chemotherapy-bearing hosts are summarized. BACKGROUND Glutamine is the most abundant free amino acid in the body. The tumor tissue, like a “glutamine network” consumes a large amount of glutamine, which promotes the occurrence of cachexia. In vitro studies, the growth of tumor cells depends on the results of glutamine so that people do not clinically replenish glutamine in cancer patients. Methods The results of studies on the relationship between glutamine and tumor-bearing hosts receiving radiotherapy and chemotherapy were summarized and summarized. Results A large number of in vivo studies have shown that glutamine supplementation will not only cause tumor growth, but will also inhibit the growth of the tumor by stimulating the body’s immune system. When receiving radiotherapy and chemotherapy in the body, glutamine protects the body and increases the selectivity of chemotherapy for tumors. Conclusions Prospective, randomized studies are also needed to demonstrate the safety and efficacy of glutamine supplementation in patients receiving radiotherapy and chemotherapy.