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目的:建立皮肤光老化动物模型以及积雪苷霜软膏对光老化防护作用的研究。方法:采取高剂量中波紫外线和长波紫外线短期联合照射的方法,建立皮肤光老化的实验动物模型。每天每次照紫外光后的间歇,在紫外线照射区域的皮肤上外涂积雪苷霜软膏。结果:与正常皮肤区域和外涂积雪苷区皮肤相比较,紫外线照射区皮肤的含水量和皮肤弹性均下降,黑色素指数增高,差异有显著性(P<0.05);外涂积雪苷区,正常皮肤区域分别与紫外线照射区皮肤比较皮肤组织的羟脯氨酸含量,差异有显著性。结论:短期高强度的紫外线照射能够引起皮肤光老化的表现。积雪苷对紫外线照射所造成的光老化的损害的有修复和保护作用。
Objective: To establish an animal model of photoaging of skin and the protective effect of asiaticoside cream on photoaging. Methods: Experimental animal models of skin photoaging were established by short-term high-dose UVB and UVB irradiation. Each time every day according to the intermittent ultraviolet light in the ultraviolet radiation area of skin overcast cream cream ointment. Results: Compared with the normal skin area and the topical coated glycosylated skin, the water content and the skin elasticity of the skin in the ultraviolet radiation area decreased and the melanin index increased, the difference was significant (P <0.05) Respectively, compared with the skin of ultraviolet radiation hydroxyproline content of skin tissue, the difference was significant. Conclusion: Short-term high-intensity ultraviolet radiation can cause skin photo-aging. Asiaticoside has the repair and protection against the damage of photo-aging caused by ultraviolet radiation.