论文部分内容阅读
目的:观察苦参碱注射液联合薄芝糖肽治疗慢性乙型肝炎(CHB)的疗效。方法:选择慢性乙型肝炎患者144例,随机分成治疗组72例,对照组72例,治疗组运用苦参碱注射液联合薄芝糖肽治疗;对照组单用重组人干扰素α-2b注射液治疗,疗程均为6个月,观察两组患者治疗前后肝功能及乙肝病毒标志物的变化情况。结果:苦参碱注射液联合薄芝糖肽治疗CHB,降ALT有效率为91.8%,HBV-DNA阴转率为31.9%,HBeAg阴转率为39.0%,与干扰素治疗CHB疗效相近,且治疗过程中末发现明显不良反应。结论:苦参碱注射液联合薄芝糖肽治疗CHB安全有效,与单用干扰素治疗CHB疗效相近。
Objective: To observe the curative effect of matrine injection combined with bilobatin on chronic hepatitis B (CHB). Methods: A total of 144 patients with chronic hepatitis B were randomly divided into treatment group (n = 72) and control group (n = 72). The treatment group was treated with matrine injection combined with bilobatin. The control group received recombinant interferon α-2b Liquid treatment, treatment were 6 months, observed two groups of patients before and after treatment of liver function and hepatitis B virus markers changes. Results: Matrine injection combined with bilobatin on CHB decreased the effective rate of ALT by 91.8%, the negative conversion rate of HBV-DNA was 31.9%, the negative conversion rate of HBeAg was 39.0%, which was similar to the treatment of CHB by interferon No significant adverse reactions were found during treatment. Conclusion: Matrine injection combined with bilobatin on CHB is safe and effective, which is similar to the treatment of CHB with interferon alone.