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[目的]了解住院分娩产妇乙肝病毒(Hepatitis B virus)感染检测及新生儿首针乙肝疫苗(First dose of hepatitis B vaccine,HepB1)接种情况,为进一步完善新生儿乙肝免疫预防策略提供参考。[方法]对2004～2008年山东省各级医疗机构产科每月上报的产妇HBV感染检测和新生儿HepB1接种资料进行分析。[结果]山东省2004～2008年住院分娩产妇HBV感染检测率逐年升高,2008年达到85.22%;产妇HBsAg阳性率保持在较低水平,平均为3.32%。医院出生新生儿HepB1及时接种率平均为96.76%,未及时接种的主要原因为早产和/或低出生体重(占48.15%)以及患病(占35.01%)。[结论]山东省新生儿HepB1及时接种率已达到较高水平。提高产妇HBV感染检测率,科学制订不同HBV感染状态产妇所生新生儿免疫方案对提高HBV母婴阻断率有重要意义。
[Objective] To understand the detection of hepatitis B virus (HBV) infection in hospitalized women and the first dose of hepatitis B vaccine (HepB1) in newborns, so as to provide reference for further improvement of newborn hepatitis B immunization strategy. [Method] The data of maternal HBV infection and newborns HepB1 inoculation reported monthly from obstetrics department of medical institutions at all levels in Shandong province from 2004 to 2008 were analyzed. [Results] The detection rate of HBV infection in hospitalized delivery in Shandong Province from 2004 to 2008 increased year by year, reaching 85.22% in 2008; the positive rate of HBsAg in maternal women remained at a low level with an average of 3.32%. The average timely vaccination rate of newborn HepB1 in hospital was 96.76%. The main reasons for the lack of timely vaccination were premature birth and / or low birth weight (48.15%) and prevalence (35.01%). [Conclusion] The timely vaccination rate of HepB1 in neonates in Shandong Province has reached a high level. Improve maternal detection rate of HBV infection, scientific development of different status of HBV infection of mothers born newborn immunization program to improve the blocking rate of HBV maternal and infant is of great significance.