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Chlamydophila pneumoniae(C.pneumoniae) is an obligate,intracellular bacterium associated with a wide variety of acute and chronic diseases.C.pneumoniae infection is characterized by persistence and immunopathological damage to host target tissues,including the lung.Over the past 20 years,a variety of studies have investigated a possible link between C.pneumoniae infection and atherosclerosis,because of its role in all stages of atherosclerosis,from initial inflammatory lesions to plaque rupture.In the current highly active antiretroviral therapy(HAART) era,many human immunodeficiency virus(HIV)-infected patients are experiencing health problems that accompany the aging process,mainly the risk of cardiovascular disease(CVD).There is renewed interest in a link between atherosclerotic CVD and as yet poorly defined environmental exposures,including infectious agents.On the one hand,the patient with HIV and lipodystrophy caused by HAART and exacerbated by C.pneumoniae infection could be a factor of risk for atherosclerosis.An assessment of the therapyagainst C.pneumoniae and HAART should always be conducted.It is advisable that HIV-acquired immune deficiency syndrome patients undergo a serological test to determine exposure to C.pneumoniae and to assess treatment options.On the other hand,in patients with a positive serology to C.pneumoniae,an increment of the body mass index has been found; therefore,it is probable that the recurrent infection may play an important role in creating adverse endothelial conditions allowing the infection by C.pneumoniae in its chronic form,to damage the endothelial surface.Vascular studies would be necessary for corroboration.
Chlamydophila pneumoniae is an obligate, intracellular bacterium associated with a wide variety of acute and chronic diseases. C. pneumoniae infection is characterized by persistence and immunopathological damage to host target tissues, including the lung. Over the past 20 years, a variety of studies have investigated a possible link between C. pneumoniae infection and atherosclerosis, because of its role in all stages of atherosclerosis, from initial inflammatory lesions to plaque rupture. the current highly active antiretroviral therapy (HAART) era, many human immunodeficiency virus (HIV) -infected patients are experiencing health problems that accompany the aging process, mainly the risk of cardiovascular disease (CVD). There is renewed interest in a link between atherosclerotic CVD and as yet poorly defined environmental exposures, including infectious agents. On the one hand, the patient with HIV and lipodystrophy caused by HAART and exacerbated by C. pneumoniae infection could be af Actor of risk for atherosclerosis. An assessment of the therapy of cancer. C. pneumoniae and HAART should always be conducted. It is advisable that HIV-acquired immune deficiency syndrome patients undergo a serological test to determine exposure to C. pneumoniae and to assess treatment options. On the other hand, in patients with a positive serology to C. pneumoniae, an increment of the body mass index has been found; therefore, it is probable that the recurrent infection may play an important role in creating adverse endothelial conditions allowing the infection by C . pneumoniae in its chronic form, to damage the endothelial surface. Vascular studies would be necessary for corroboration.