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目的探讨脑心通胶囊治疗代谢综合征(MS)的临床疗效。方法选取2008年1月—2012年1月北京市昌平区医院收治的MS患者200例,根据治疗方法不同将其分为治疗组与对照组,各100例。对照组患者予以二甲双胍肠溶片治疗,治疗组患者予以脑心通胶囊治疗。观察两组患者临床疗效、血压、心率、体质指数(BMI)、腰围及血清生化指标〔总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、空腹血糖(FBG)、血肌酐(SCr)、尿微量蛋白(MUAC)〕变化情况。结果治疗组患者总有效率高于对照组,差异有统计学意义(P<0.05);治疗组患者收缩压、舒张压、BMI低于对照组,腰围小于对照组,差异有统计学意义(P<0.05),两组患者心率比较,差异无统计学意义(P>0.05);治疗组患者TC、TG、FBG、SCr、MUAC水平低于对照组,HDL-C水平高于对照组,差异有统计学意义(P<0.05)。结论脑心通胶囊治疗MS的临床疗效显著,可改善临床症状,降低患者血压、心率及体质量。
Objective To investigate the clinical efficacy of Naoxintong capsule in the treatment of metabolic syndrome (MS). Methods Two hundred MS patients admitted to Changping District Hospital in Beijing from January 2008 to January 2012 were selected and divided into treatment group and control group with 100 cases in each group according to different treatment methods. Patients in the control group were treated with metformin enteric-coated tablets, and patients in the treatment group were given Naoxintong capsules. The clinical efficacy, blood pressure, heart rate, body mass index (BMI), waist circumference and serum biochemical parameters (TC, TG, HDL-C and fasting blood glucose FBG), serum creatinine (SCr), urine microalbumin (MUAC)〕 changes. Results The total effective rate in the treatment group was higher than that in the control group (P <0.05). The systolic blood pressure, diastolic blood pressure and BMI in the treatment group were lower than those in the control group, and the waist circumference was smaller than the control group (P <0.05). There was no significant difference in heart rate between the two groups (P> 0.05). The levels of TC, TG, FBG, SCr and MUAC in the treatment group were lower than those in the control group, and the HDL-C levels were higher than those in the control group Statistical significance (P <0.05). Conclusion Naoxintong capsule treatment of MS clinical significant effect, can improve clinical symptoms, reduce blood pressure, heart rate and body weight.