Waller变性的最初报告

• 作 者: Waller Augustus Volney 李晓光
• 机 构: 山东省千佛山医院骨科,
• 出 处: 中国矫形外科杂志
• 发表日期: 2014年03期
• 关键词: 迂曲扩张 病理学变化 雪旺细胞 Waller变性 远端的 不规则状 纺缍形 神经外膜 纤维结构 后所

本研究目的旨在探讨切断周围神经与脑或脊髓的连接后所发生的各种病理学变化,本文仅报告青蛙的舌下神经切断后远端的病理变化。在最初的4 d内未发现变化,第5 d神经外膜出现迂曲扩张,神经纤维(轴突)呈不规则状,第10 d发生轴突崩解,镜下到处见纺锤形结构,此时已经观察不到雪旺细胞。12~15 d后几乎见不到单一的纤维结构,呈颗粒状的轴突开始吸收。笔者认为,上述变性改变,并非青蛙的舌下神经特异性变化,其他动物、其他神经也同样会发生。

The purpose of this study was to investigate the pathological changes that occur after the connection between the peripheral nerves and the brain or spinal cord is severed. This article reports only the distal pathological changes following fronto-hypoglossal nerve transection. In the first 4 days, no change was found. On the 5th day, the epineurium appeared tortuous dilation, the nerve fiber (axon) was irregular, the axon disintegrated on the 10th day and the spindle-shaped structure was seen everywhere Schwann cells have not been observed. Almost no single fibrous structure was seen after 12 to 15 days and granular axons began to absorb. The author believes that the above changes in degeneration, not the frog’s sublingual nerve-specific changes in other animals, other nerves also occur.