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目的旨在探讨酚妥拉明与呋塞米联用治疗顽固性心力衰竭的疗效。方法59例顽固性心衰患者应用酚妥拉明10～20mg加入5%葡萄糖注射液250ml中以6～15滴/min缓慢静脉滴注,1～2次/d,呋塞米40～80mg分2次加入滴管中,直至心衰症状缓解。结果59例患者中55例用药后24h内症状、体征有不同程度减轻、尿量增多,5～7d心功能由治疗前Ⅳ级恢复到治疗后Ⅰ～Ⅱ级,总有效率达92.6%。结论酚妥拉明联用呋塞米能明显减轻心脏前后负荷而取得较为满意的效果,经济方便,不失为一种安全有效的方法。
Purpose To investigate the efficacy of phentolamine combined with furosemide in the treatment of refractory heart failure. Methods Fifty-nine patients with refractory heart failure were treated with intravenous infusion of phentolamine 10-20 mg in 5% dextrose injection at a slow rate of 6-15 drops / min, once / twice, and 40-80 mg of furosemide 2 times into the dropper, heart failure symptoms until ease. Results The symptoms and signs of 55 patients were relieved to varying degrees in the 55 patients within 24 hours after treatment, and the urine output increased. The cardiac function recovered from grade Ⅳ to grade Ⅰ ~ Ⅱ after 5 ~ 7 d, and the total effective rate reached 92.6%. Conclusion Phentolamine combined with furosemide can significantly reduce the load before and after the heart to obtain more satisfactory results, economical and convenient, after all, a safe and effective method.