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目的了解抗艾滋病病毒(HIV)治疗情况并进行疗效评价,探索抗病毒治疗(ART)病毒抑制失败的影响因素,提出改进ART效果的措施。方法收集成都市疾病预防控制中心性病艾滋病防治科所提供的成都市HIV感染者/艾滋病(AIDS)病人(简称HIV/AIDS病人)抗病毒治疗的随访资料,对资料进行清理分析。结果共收集1682例HIV/AIDS病人,经标准方案治疗1年后CD_4~+T淋巴细胞计数从(184.49±103.82)个/μL上升到(313.11±157.41)个/μL,ART前后差异有统计学意义(t=-40.778,P<0.001)。病毒抑制失败86例,失败率为5.1%。拟合多因素Logistic回归分析发现,年龄[比值比(OR)=2.073,95%可信区间(CI)=1.012~4.248,P=0.046]、漏服(OR=5.994,95%CI=2.314~15.528,P<0.001)及治疗方案(OR=2.059,95%CI=1.223~3.467,P=0.007)与病毒抑制失败的关系具有统计学意义。结论漏服是影响病毒抑制失败的主要因素,应关注老年患者的病毒抑制情况,通过提高患者依从性和尽量使用最优治疗方案来降低病毒抑制失败率。
Objective To understand the situation of anti-HIV treatment and to evaluate its curative effect, to explore the influencing factors of the failure of anti-virus treatment (ART) virus and to propose measures to improve the effect of ART. Methods The follow-up data of antiretroviral treatment of HIV-infected / AIDS patients (HIV / AIDS patients) provided by STD and AIDS prevention and control department of Chengdu Center for Disease Control and Prevention were collected and the data were analyzed. Results A total of 1682 HIV / AIDS patients were collected. After one year of standard regimen, CD_4 ~ + T lymphocyte counts increased from (184.49 ± 103.82) / μL to (313.11 ± 157.41) / μL, Significance (t = -40.778, P <0.001). 86 cases of failure to suppress the virus, the failure rate was 5.1%. Multivariate Logistic regression analysis showed that age (OR = 2.073, 95% confidence interval (CI) = 1.012-4.284, P = 0.046) 15.528, P <0.001) and the treatment regimen (OR = 2.059, 95% CI = 1.223-3.467, P = 0.007) were significantly correlated with the failure of viral suppression. Conclusions The missed service is the main factor that affects the failure of virus inhibition. Attention should be paid to the virus suppression in elderly patients, and the failure rate of virus inhibition should be reduced by improving patient compliance and using the best treatment plan as far as possible.