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目的:探讨调脂积治疗脂肪肝的药效学机制。方法:采用CCL4合并高脂乳剂建立大鼠脂肪肝模型,以易善复作对照,测定肝组织病理学、血清及肝组织甘油三酯、胆固醇,丙二醛(MDA),超氧化物歧化酶(SOD)及肝功能部分生化指标。结果:调脂积可减轻肝组织损伤和脂肪变性程度,降低血清及肝组织甘油三酯,胆固醇,提高机体SOD活性,降低肝组织中脂质过氧化产物丙二醛的含量。结论:调脂积有显著的抗肝组织脂肪变性,抗过氧化损伤,保护肝脏,治疗脂肪肝的作用。
Objective: To explore the pharmacodynamic mechanism of lipid accumulation in the treatment of fatty liver. METHODS: Fatty liver model of rats was established with CCL4 combined with high-fat emulsion. Histopathology, serum and hepatic tissue triglycerides, cholesterol, malondialdehyde (MDA), superoxide dismutase (SOD) were measured in the liver tissue. (SOD) and some biochemical indicators of liver function. RESULTS: Lipid-regulation could reduce the degree of hepatic injury and steatosis, reduce serum and liver triglyceride, cholesterol, increase SOD activity, and reduce the content of malondialdehyde in lipid peroxidation product. Conclusion: Lipid regulation has significant anti-hepatic steatosis, anti-peroxidative damage, protection of the liver, and treatment of fatty liver.