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已经在许多肝硬化患者的肾小球系膜中发现有IgA和少量其它免疫球蛋白及C_3沉积。这种组织学异常被称为“肝硬化性肾小球肾炎(肝硬化性GN)”。肝硬化性GN是否为一个独立的病种尚有争议。有人认为,这种情况可能仅反映了肝硬化和原发性IgA肾病这两个无关疾病的共同发生。由于对照性双盲法研究尚少而尸检及活检又固有选择偏倚,故实难断定。虽然如此,肝硬化患者经电镜和免疫荧光镜检有肾小球异常的可达50～100％。而且,肝硬化性GN患者在临床血清学上确有其特殊征象。Berger指出:“IgA作为主要的免疫球蛋白沉积很罕见于急性GN、急进性GN、特发性膜性或膜增殖性GN,因此,绝大多数肝硬化患者中的
IgA and small amounts of other immunoglobulins and C_3 deposits have been found in the glomerular mesangium of many cirrhosis patients. This histological abnormality is called “cirrhosis glomerulonephritis (cirrhosis GN)”. Whether or not cirrhotic GN is an independent disease is controversial. Some people think that this situation may only reflect the cirrhosis and primary IgA nephropathy, a common occurrence of two unrelated diseases. Due to the controversial double-blind study is still less autopsy and biopsy inherent selection bias, it is hard to determine. Nonetheless, patients with cirrhosis by electron microscopy and immunofluorescence microscopy of glomerular abnormalities up to 50 ~ 100%. Moreover, patients with cirrhotic GN do have their own specific clinical signs of serology. Berger pointed out: "IgA as a major immunoglobulin deposition is very rare in acute GN, aggressive GN, idiopathic membranous or proliferative GN, therefore, the vast majority of patients with cirrhosis