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[目的]动态观察冠心病患者使用阿托伐他汀治疗前后肱动脉血管内皮功能的变化,探讨他汀类药物在冠心病防治中的意义。[方法]住院确诊的冠心病患者200例,给予阿托伐他汀20mg口服,观察4周,分别于治疗前、后测定肱动脉血管内皮功能,同时测定冠心病患者的血脂水平。[结果]阿托伐他汀治疗1周后病人TC、LDL水平无明显下降,服药1周后肱动脉血管内皮功能改善,2周后病人TC、LDL水平下降,4周后病人TC、LDL水平明显下降,肱动脉血管内皮功能明显改善。[结论]阿托伐他汀对冠心病患者的血管内皮功能有改善作用,且改善作用发生在降脂作用发挥前,提示冠心病患者应早期口服阿托伐他汀改善血管内皮功能。
[Objective] To dynamically observe the changes of vascular endothelial function of brachial artery before and after treatment with atorvastatin in patients with coronary heart disease and to explore the significance of statins in the prevention and treatment of coronary heart disease. [Methods] 200 hospitalized coronary heart disease patients were given orally with atorvastatin 20 mg for 4 weeks. The endothelial function of brachial artery was measured before and after treatment, and the level of blood lipid in patients with coronary heart disease was also measured. [Results] There was no significant decrease of TC and LDL after at least 1 week of atorvastatin treatment. The endothelial function of brachial artery was improved after 1 week of treatment. The levels of TC and LDL decreased after 2 weeks and the levels of TC and LDL were obvious after 4 weeks Decline, brachial artery endothelial function improved significantly. [Conclusion] Atorvastatin can improve the function of vascular endothelium in patients with coronary heart disease, and the improvement effect occurs before the lipid-lowering effect is exerted, suggesting that atorvastatin should be given orally in early stage of coronary heart disease to improve the vascular endothelial function.