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目的:探讨通莲汤辅助治疗食管癌对患者血清p53、survivin的抑制作用及对预后影响。方法:选取我院2012年8月~2015年8月收治60例食管癌患者,按随机数字法分为对照组(28例)与观察组(32例)。对照组采取微波热疗,观察组在对照组基础上联合通莲汤进行治疗,比较两组治疗前后血清p53和survivin阳性表达率、近期疗效及治疗前后NRS分级、KPS评分。结果:两组治疗前血清p53、survivin阳性率及NRS分级、KPS评分的差异均P>0.05;治疗后观察组血清p53阳性率降低至25.0%,survivin阳性率降低至65.6%,均低于对照组,NRS分级为(4.2±0.8)级,低于对照组;KPS评分为(82.1±6.3)分,高于对照组,差异均有统计学意义(P<0.05)。观察组治疗总有效率为75.0%,高于对照组50.0%,差异P<0.05。结论:通莲汤辅助治疗食管癌可发挥扶正祛邪、祛瘀散结、行气止痛之功,有效抑制患者血清p53及survivin表达,减轻疼痛并改善健康状况,利于预后改善。
Objective: To investigate Tonglintang adjuvant treatment of esophageal cancer on patients with serum p53, survivin inhibition and prognosis. Methods: Sixty patients with esophageal cancer were selected from August 2012 to August 2015 in our hospital. The patients were divided into control group (n = 28) and observation group (n = 32) according to random number method. The control group was treated with microwave hyperthermia. The observation group was treated with Lian Tong Lian Tang on the basis of the control group. The positive rate of p53 and survivin in the two groups were compared before and after treatment. The curative effect and NRS grade and KPS before and after treatment were compared. Results: The positive rates of p53, survivin, NRS and KPS in two groups before treatment were all significantly higher than those in control group (P> 0.05). The positive rate of p53 in the observation group decreased to 25.0% and the positive rate of survivin decreased to 65.6% Group, the NRS grade was (4.2 ± 0.8) grade, lower than the control group; KPS score was (82.1 ± 6.3) points, higher than the control group, the difference was statistically significant (P <0.05). The observation group, the total effective rate was 75.0%, higher than the control group 50.0%, difference P <0.05. Conclusion: Tonglian decoction can effectively relieve the expression of p53 and survivin, relieve the pain and improve the health of esophageal cancer, which can improve the prognosis.