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目的观察短期应用福辛普利联合肾康注射液对早期糖尿病患者肾功能及尿蛋白的影响。方法早期糖尿病肾病患者43例,年龄35-70岁;男性24例,女性19例,分为治疗组23例,对照组20例,治疗组给予福辛普利片(上海施贵宝)10mg,0.9%氯化钠注射液250ml中加入肾康注射液(世纪盛康药业有限公司)60ml静脉滴注,每日一次,连续14日;对照组给予依那普利(扬子江)10mg,口服,每日一次;控制血糖、血脂等其他方法各组相同。结果治疗后后两组的尿微量白蛋白、血肌酐水平不同程度减低,治疗组低于对照组,差异有统计学意义,治疗前后两组血压、血糖差异无统计学意义。结论 ACEI联合肾康注射液及单独应用ACEI均能明显降低早期糖尿病患者尿蛋白,但联合组疗效更为显着。
Objective To observe the effect of short-term use of fosinopril combined with Shenkang injection on renal function and urinary protein in patients with early stage diabetes mellitus. Methods Thirty-three patients with early diabetic nephropathy, aged 35-70 years, 24 males and 19 females, were divided into treatment group (23 cases) and control group (20 cases). The treatment group was given fosinopril tablets Sodium chloride injection 250ml add Shen Kang injection (Century Shing Hong Pharmaceutical Co., Ltd.) 60ml intravenously, once daily for 14 days; the control group was given enalapril (Yangtze River) 10mg, orally, daily Once; control blood sugar, blood lipids and other methods of the same in all groups. Results After treatment, urinary albumin and serum creatinine levels decreased to some extent in the treatment group, but the difference was statistically significant. There was no significant difference in blood pressure and blood glucose between the two groups before and after treatment. Conclusion ACEI combined with Shenkang injection and ACEI alone can significantly reduce urinary protein in patients with early diabetes, but the combination group is more effective.