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目的探讨尸检肺水肿病理形态改变及TNF-α、SP-B表达对发病机制及临床治疗的相关性研究。方法 20例对照组病例因肺部肿瘤行右肺全切术,经病理学检查右肺中叶没有肿瘤细胞侵犯。与76例尸检组光镜观察肺组织病理学改变,并应用免疫组化方法测定病例肺组织SP-B、TNF-α的含量。结果 76例尸检组肺组织SP-B含量较对照组明显减少,TNF-α含量明显增多(P<0.05)。结论 TNF-α、SP-B在导致各型肺水肿发生的肺损伤中均有明显的相关性;SP-B的特异性较SP-A高,各型肺水肿组织SP-B免疫组化显示肺泡Ⅱ型上皮细胞的表达明显减弱。
Objective To investigate the pathological changes of autopsy pulmonary edema and the correlation between the pathogenesis and clinical treatment of TNF-α and SP-B expression. Methods Twenty patients in the control group underwent right lung resection due to lung tumors. There was no tumor cell invasion in the middle right lung by pathological examination. And 76 cases of autopsy group were observed by light microscopy lung histopathological changes, and the application of immunohistochemical methods to determine the cases of lung tissue SP-B, TNF-α content. Results The content of SP-B in the lung tissue of 76 autopsy groups was significantly lower than that of the control group, and the content of TNF-α was significantly increased (P <0.05). Conclusions TNF-α and SP-B have obvious correlation in the lung injury of various types of pulmonary edema. SP-B is more specific than SP-A, SP-B immunohistochemistry of various types of pulmonary edema Alveolar type Ⅱ epithelial cells were significantly weakened.