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目的探讨氧化乐果染毒大鼠膈肌损害及盐酸戊乙奎醚对其保护作用。方法96只Wistar大鼠腹腔注射氧化乐果建立有机磷中毒模型,并给予阿托品及盐酸戊乙奎醚治疗,随机分为四组：盐水对照组、中毒对照组、阿托品+氯磷定治疗组、盐酸戊乙奎醚+氯磷定治疗组,测定各组大鼠染毒后2 h血液胆碱酯酶(AChF)和肌酸激酶(CK),观察染毒后不同时间膈肌组织病理学和超微结构的改变。结果盐酸戊乙奎醚治疗组大鼠各时段膈肌病理损害较阿托品治疗组明显为轻,病变恢复快。结论膈肌纤维坏死是有机磷农药中毒所致呼吸肌麻痹的可能原因之一,盐酸戊乙奎醚对氧化乐果中毒大鼠的膈肌有明确的保护作用,推测其有预防中间期肌无力的作用。
Objective To investigate the protective effects of amylose hydrochloride on diaphragmatic muscle damage induced by omethoate in rats. Methods 96 Wistar rats were injected omeprazole intraperitoneally to establish the model of organophosphate poisoning. The rats were treated with atropine and penehyclidine hydrochloride and were randomly divided into four groups: saline control group, poisoned control group, atropine + chlorophosphorus treatment group, Penehyclidine hydrochloride and chlorpromazine treatment group, blood cholinesterase (AChF) and creatine kinase (CK) were measured at 2 h after exposure in each group. The pathological changes of hyperplasia Microstructure changes. Results Penehyclidine hydrochloride treatment group rats at each time diaphragm pathological damage than the atropine treatment group was significantly lighter, faster recovery of the disease. Conclusion Diaphragmatic necrosis is one of the possible causes of respiratory muscle paralysis caused by organophosphorus pesticide poisoning. Penehyclidine hydrochloride has a definite protective effect on diaphragmatic muscle of omethoate-induced rats, and it is presumed that it has the effect of preventing midvascularization .