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目的比较慢性鼻窦炎伴有鼻息肉(CRSwNP)和不伴鼻息肉(CRSsNP)患者中血清嗜酸粒细胞阳离子蛋白(ECP)水平的差异。方法采用ImmunoCAP100E系统,检测99例CRSwNP患者和59例CRSsNP患者的血清ECP水平,并与健康对照组84例比较。结果三组间血清ECP水平的差异有统计学意义(P<0.05),其中CRSwNP组明显高于健康对照组(P<0.01),尤其是中-重度患者与健康对照组比较血清ECP水平显著升高(P<0.01)。但CRSwNP组与CRSsNP组比较,差异无统计学意义(P>0.05);两组轻度与中-重度患者之间分别进行比较,差异均无统计学意义(P>0.05)。结论嗜酸粒细胞性炎症反应在慢性鼻窦炎伴或不伴鼻息肉的发病中可能均发挥了作用,但疾病的严重程度与炎性指标ECP的血清浓度之间未见明显相关性,有待进一步探讨。
Objective To compare the differences of serum eosinophil cationic protein (ECP) levels between patients with chronic sinusitis and nasal polyps (CRSwNP) and without nasal polyps (CRSsNP). Methods ImmunoCAP100E system was used to detect serum ECP levels in 99 patients with CRSwNP and 59 patients with CRSsNP and compared with 84 healthy controls. Results There was a significant difference in serum ECP levels among the three groups (P <0.05), of which CRSwNP group was significantly higher than that of healthy control group (P <0.01), especially in moderate-severe patients and healthy controls High (P <0.01). However, there was no significant difference between CRSwNP group and CRSsNP group (P> 0.05). There was no significant difference between the two groups in mild and moderate-severe cases (P> 0.05). Conclusions Eosinophilic inflammation may play an important role in the pathogenesis of chronic sinusitis with or without nasal polyps. However, there is no obvious correlation between the severity of the disease and the serum concentration of ECP, which needs further study Discussion.