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目的:了解长春市婴幼儿巨细胞病毒感(CMV)染情况及临床特点。方法:用荧光定量PCR方法对711例疑似CMV感染婴幼儿尿液标本中巨细胞病毒CMV-DNA进行检测,同时分析临床资料。结果:婴幼儿CMV感染率为13.64%(97/711);CMV感染年龄最小为出生1天,中位年龄为7月龄,其中89.69%为<24月龄婴幼儿;城乡分布为1∶1.94,男女之比为1.02∶1。症状为发热57例、咳喘72例、腹泻6例、出血5例、惊厥2例、排尿异常2例;体征为黄疸1例、肝脾大6例;化验检查肝功异常83例、心肌酶学异常65例;临床诊断肺炎72例、肠炎6例、母乳性黄疸1例、消化道出血1例、特发性血小板减少性紫癜5例、泌尿感染2例、先天心脏病7例、手足口病2例、先天性梅毒1例。结论:CMV感染可致多脏器损害,临床表现特异性差,早期进行CMV-DNA检测及时发现及早治疗活动性感染患儿非常必要。
Objective: To understand the infants and young children’s cytomegalovirus infection (CMV) infection and clinical features in Changchun. Methods: Cytomegalovirus CMV-DNA in 711 urine samples from infants and young children suspected of CMV infection was detected by real-time fluorescence quantitative PCR and the clinical data were analyzed. Results: The infection rate of CMV in infants and young children was 13.64% (97/711). The youngest age of CMV infection was 1 day of birth, the median age was 7 months, of which 89.69% were infants <24 months old. The distribution of urban and rural areas was 1: 1.94 , Male to female ratio of 1.02: 1. Symptoms of 57 cases of fever, cough and asthma in 72 cases, 6 cases of diarrhea, bleeding in 5 cases, 2 cases of convulsions, urination abnormalities in 2 cases; signs of jaundice in 1 case, hepatosplenomegaly in 6 cases; 65 cases of abnormal learning; clinical diagnosis of pneumonia in 72 cases, 6 cases of enteritis, breast milk jaundice in 1 case, gastrointestinal bleeding in 1 case, idiopathic thrombocytopenic purpura in 5 cases, urinary tract infection in 2 cases, congenital heart disease in 7 cases, 2 cases of disease, 1 case of congenital syphilis. Conclusion: CMV infection can cause multiple organ damage, poor clinical manifestations, early detection of CMV-DNA in early detection of active infection in children is very necessary.