甲氧氯普胺给药时机对环磷酰胺所致胃肠道不良反应的影响(摘要)

• 作 者: 王颖 梁宏 周娟 曹景泉
• 机 构: 第202医院风湿免疫科,第202医院风湿免疫科,第202医院风湿免疫科,第202医院风湿免疫科 110003,110003,110003,110003
• 出 处: 沈阳部队医药
• 发表日期: 2002年02期
• 关键词: 胃肠道不良反应 甲氧氯普胺 系统性红斑狼疮 给药时机 肾损害 用药时机 环磷酞胺 观察组 呕吐反应 氮芥

环磷酰胺(CTX)对系统性红斑狼疮(SLE)的肾损害疗效确切,但常引起胃肠道不良反应。甲氧氯普胺常用于减轻CTX的胃肠道不良反应。为探讨CTX的用药时机是否对疗效有影响,本文进行了对比观察。28例SLE,男3例,女25例;平均年龄28.3±12.5岁;平均病程11.6±8.3个月;随机分为观察组和对照组各14例。两组均静滴CTX 1.0g,每月1次。观察组在静滴CTX后5h肌注甲氧氯普胺10mg;对照组在静滴CTX的同时肌注

Cyclophosphamide (CTX) is effective in treating renal damage in systemic lupus erythematosus (SLE), but often causes gastrointestinal adverse reactions. Metoclopramide is commonly used to reduce the gastrointestinal side effects of CTX. In order to explore whether the CTX medication timing has an effect on the curative effect, this paper conducted a comparative observation. 28 cases of SLE, 3 males and 25 females; mean age 28.3 ± 12.5 years; mean duration of 11.6 ± 8.3 months; were randomly divided into observation group and control group of 14 cases. Two groups were intravenous CTX 1.0g, once a month. In the observation group, metoclopramide 10 mg was injected intramuscularly 5 h after intravenous infusion of CTX. In the control group, intramuscular injection of CTX