Enhanced lysosome escape mediated by 1,2-dicarboxylic-cyclohexene anhydride-modified poly-L-lysine d

• 作 者: Jianmin Shen Jing Chen Jingbo
• 机 构: SchoolofLifeSciences,ShenzhenFollowingPrecisionMedicalResearchInstitute,SchoolofBasicMedicalSciences
• 出 处: 亚洲药物制剂科学(英文)
• 发表日期: 2020年6期
• 关键词: Antisense oligodeoxynucleotide(ASODN) Gene delivery Dendrigraft poly-L-lysines(D
• 基金项目: supported by the National Natural Science Foundation of China Fund(No 81541060),Science and Technology Projects from the Science Technology and Innovation Committee of Shenzhen Municipality(grant no.J

Antisense oligodeoxynucleotide(ASODN)can directly interfere a series of biological events of the target RNA derived from tumor cells through Watson-Crick base pairing,in turn,plays antitumor therapeutic roles.In the study,a novel HIF-1αASODN-loaded nanoco