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目的观察豚鼠单侧内淋巴囊破坏后前庭功能损伤、中枢代偿及代偿的稳定性等特点。方法将30只健康豚鼠随机等分为对照组和实验组,用正弦角加速度试验评估前庭功能。硫喷妥钠腹腔注射诱导前庭失代偿,观察注射后静态姿势、紧张性眼位移及自发性眼震,同步记录眼震电图。结果①内淋巴囊破坏后第8周正弦摆动性前庭眼震的慢相速度有明显失对称。②硫喷妥钠可诱导前庭失代偿现象,损伤越重,代偿愈不稳定,越易诱发失代偿。以紧张性眼位移最常见,自发性眼震最少。③病理切片示内淋巴囊破坏后第8周蜗管有明显积水。结论内淋巴囊破坏后可引起前庭功能损害,由于中枢代偿而不表现出明显的前庭功能紊乱症状,但这种代偿是不稳定的。
Objective To observe the vestibular dysfunction, central compensatory and compensatory stability after guinea pig unilateral lymphatic sac destruction. Methods Thirty healthy guinea pigs were equally divided into control group and experimental group, and vestibular function was evaluated by sinusoidal acceleration test. Intraperitoneal injection of thiopental induced induction of vestibular decompensation, observed post-injection static posture, tension eye displacement and spontaneous nystagmus, synchronized recording of electronystagmus. Results ① The slow phase velocity of sinusoidal oscillating vestibular nystagmus in the 8th weeks after the endolymphatic sac rupture was significantly asymmetric. ② thiopental sodium can induce vestibular decompensation phenomenon, the more serious injury, compensatory instability, the more likely to induce decompensation. The most common ocular displacement, spontaneous nystagmus at least. ③ pathological section shows the lymphatic sac after 8 weeks of significant vascularization water. Conclusion The rupture of the endolymphatic sac can cause damage to the vestibular function. Because of central compensation, it does not show obvious signs of vestibular dysfunction, but this compensation is not stable.