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从止咳、平喘草药野罂粟PapavernudicauleL．朔果中分得4个Isopavine型生物碱，经理化常数及波谱分析确定为瑞芙热米定（reframidine，Ⅱ）、黑龙辛甲醚（amurensinine，Ⅳ）、黑龙辛（amurensine，Ⅴ）和refractamine（Ⅶ）。其中Ⅶ系首次从该属植物中分得。以Ⅱ，Ⅳ和Ⅴ为前体合成4个简单衍生物，药理实验表明以上化合物均有不同程度的平喘、止咳作用。
Antitussive, anti-asthma herbal wild poppy Papavernudicaule L. Four Isopavine-type alkaloids were obtained from the pods, and the management constants and spectroscopic analysis identified reframidine (II), amurensinine (IV), amurensine (V) and refractamine. (VII). Among them, VII was firstly obtained from this genus. Four simple derivatives were synthesized with II, IV and V as precursors. Pharmacological experiments showed that the above compounds all had different degrees of anti-asthmatic and antitussive effects.