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对甲苯咪唑口服乳剂在免体内的药物动力学进行研究。方法：以阿苯咪唑为内标，采用反相高效液相色谱法测定血中的甲苯咪唑浓度。流动相为：甲醇-0．01mol·L－1硫酸接缓冲浪（58：42）；流速：1ml·min-1；检测器波长：247nm。结果：标准曲线为：C（μg·ml-1）=0．6026Ai/As－0.6597（r＝0、9929）；线性范围为4.996～999．2ng·ml-1，平均回收率为（97．8±5．4）％，RSD＝5．52％。方法的精密度和重现性符合生物样品测定要求。甲苯咪唑乳剂在兔体内的AUC比片剂高出四倍还多，其它药物动力学参数如Cmax，Kat1/2（Ka），Cls，Vd等均与片剂间差异有显著性（P＜0.05）。结论：甲苯咪唑乳剂与片剂相比，吸收快，Cmax和AUC均高，为临床应用提供参考。
Pharmacokinetics of the omeprazole oral emulsion was studied in vitro. Methods: Diphenmidazole was used as internal standard, and the concentration of mebendazole in blood was determined by RP-HPLC. The mobile phase consisted of methanol-0.01 mol·L-1 sulfuric acid buffer (58:42); flow rate: 1 ml · min-1; detector wavelength: 247 nm. Results: The standard curve was: C (μg · ml-1) = 0.6026Ai / As-0.6597 (r = 0,9929). The linear range was 4.996 ~ 999.2ng · ml-1 with an average recovery of 97%. 8 ± 5.4)%, RSD = 5.52%. The precision and reproducibility of the method meet the requirements of biological samples. The AUC of rabeprazole was more than four times higher than that of the tablets. The pharmacokinetic parameters such as Cmax, Kat1 / 2 (Ka), Cls, Vd and other tablets were significantly different from those of the tablets (P <0.05 ). Conclusion: Compared with tablets, mebendazole has faster absorption and higher Cmax and AUC, which provides a reference for clinical application.