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目的比较妊娠期糖尿病(GDM)妊娠和正常妊娠孕妇血浆中Chemerin水平,探讨GDM血浆Chemerin因子的表达水平与新生儿体重的相关性。方法选取2013年7月-2014年7月河北医科大学第四医院定期产检并住院分娩的GDM孕妇50例(GDM组)和正常孕妇50例(正常组),采用酶联免疫吸附法(ELISA)检测孕24~28周、终止妊娠前母体血中和脐血中的Chemerin因子的表达水平并进行组间比较。结果 1在孕24~28周,GDM组和正常组Chemerin因子表达水平无统计学差异(t=1.161,P=0.123);在终止妊娠前和脐血中,GDM组Chemerin因子的表达水平均高于正常妊娠组,差异具有统计学意义(t=6.585、7.382,P=0.002)。2GDM组的新生儿出生体重明显高于正常组,差异具有统计学意义(t=7.108,P=0.000),而身长无统计学差异(t=0.904,P=0.150)。3相关性分析显示:分娩前母体血浆中Chemerin水平与新生儿出生体重成正相关性,与新生儿身长无明显相关性。结论 GDM孕妇终止妊娠前血浆Chemerin因子表达水平高于正常孕妇,母体血中Chemerin因子水平与新生儿出生体重成正相关性,当Chemerin水平超过0.7 mg/L时警惕巨大儿的形成。
Objective To compare the levels of Chemerin in pregnant women with gestational diabetes mellitus (GDM) and normal pregnant women, and to explore the correlation between the expression level of Chemerin in GDM plasma and body weight of neonates. Methods From July 2013 to July 2014, 50 pregnant women (GDM group) and 50 normal pregnant women (regular group) were enrolled in the Fourth Hospital of Hebei Medical University regularly. The serum levels of GDM and normal pregnant women were detected by enzyme linked immunosorbent assay (ELISA) The levels of Chemerin in maternal blood and umbilical cord blood before termination of pregnancy were detected 24 to 28 weeks gestation and compared between groups. Results1 There was no significant difference in the expression of Chemerin between GDM group and normal group (t = 1.161, P = 0.123) between 24 and 28 weeks of gestation. The levels of Chemerin in GDM group were higher than those before GDM In normal pregnancy group, the difference was statistically significant (t = 6.585, 7.382, P = 0.002). The birth weight of newborns in 2GDM group was significantly higher than that of normal group (t = 7.108, P = 0.000), but there was no significant difference in body length (t = 0.904, P = 0.150). 3 Correlation analysis showed that the level of Chemerin in maternal plasma before delivery was positively correlated with the birth weight of neonates and had no significant correlation with the length of neonates. Conclusions The level of Chemerin in pregnant women with GDM is higher than that in normal pregnant women. The level of Chemerin in maternal blood is positively correlated with the birth weight of newborns. When the level of Chemerin exceeds 0.7 mg / L, vigilance is noticed.