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本文报道平原大鼠进入海拔5100m的高原后,其主要脏器的超微结构均发生一定的损害。心肌细胞线粒体嵴断裂、溶解,肌浆网扩张,细胞间质水肿等;肾小管上皮细胞微绒毛排列紊乱,核异染色体边聚,部分线粒体呈明显髓鞘样改变;脑细胞线粒体肿胀,膜结构消失,甚至呈空泡状改变,突触前后膜不清等。经服五补口服液的大鼠脏器损伤程度较对照组明显减轻,且以肾组织为著,显示该方对高原低氧下大鼠脏器的超微结构具保护作用。以中医微观辩证角度论证该方亦表明具有良好的证效关系,同时,本项研究为其抗早衰作用提供了有力的客观证据。
This paper reports that after entering the altitude of 5100m plateau plain rats, the main organs of the ultrastructure of a certain degree of damage. Myocardial mitochondrial cristae cracked, dissolved, sarcoplasmic reticulum dilatation, interstitial edema, etc .; renal tubular epithelial cells were arranged in microvilli, nuclear heterochromosomes clustered, some mitochondria showed obvious myelin-like changes; brain cells mitochondria swelling, membrane structure Disappear, even vacuolar change, unclear synaptic membrane. Compared with the control group, the injury of organ in rats treated with Wufu oral liquid was significantly lessened, and the renal tissue was taken as the indicator that this prescription has the protective effect on the ultrastructure of the organs in rats exposed to plateau hypoxia. On the micro-dialectical perspective of traditional Chinese medicine, the party also demonstrated that it has a good relationship of evidence and efficacy. At the same time, this study provides strong objective evidence for its anti-premature senility effect.