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四、非强心甙类正性肌力药物儿茶酚胺类包括选择性和非选择性β—受体激动剂,如多巴胺、多巴酚丁胺、吡丁醇、舒喘宁、对羟苯心安等。这类药物可与心肌细胞膜上的β受体结合,激活腺苷酸环化酶,催化ATP形成CAMP。后者又激活蛋白激酶,使钙通道开放,钙离子内流,心肌收缩增强。1.多巴胺小剂量(2～5μg/kg/min)时兴奋多巴胺受体,扩张内脏和肾血管;中等剂量(6～10μg/kg/min)时β_1受体兴奋,产生显著正性肌力作用;大剂量(11～20μg/kg/min)则兴奋β_1和α受体,使周围血管、内脏和肾血管均收缩。适用于心衰伴血压下降,以小至中等剂量为宜。
Fourth, non-cardiac glycosides inotropic drugs Catecholamines include selective and non-selective β-agonists, such as dopamine, dobutamine, pirbuterol, salbutamol, paracetamol, etc. . These drugs can bind to the beta receptors on the membrane of cardiac cells, activating adenylate cyclase and catalyzing the formation of CAMP by ATP. The latter activates protein kinase, the calcium channel opening, influx of calcium, myocardial contractility. 1. Dopamine evoked dopamine receptors, dilated visceral and renal vessels at low dose (2 ~ 5μg / kg / min); β_1 receptor was stimulated at moderate dose (6-10μg / kg / min) ; High dose (11 ~ 20μg / kg / min) is excited β_1 and α receptors, the surrounding blood vessels, internal organs and renal blood vessels were contracted. For heart failure with blood pressure, small to medium dose is appropriate.