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作者用烟酰胺治疗心动过缓10例,收到一定疗效,但其中3例在治疗过程中诱发房颤。女2例、男1例,年龄48～60岁,诊断为病态窦房结综合征2例,冠心病1例。心率分别为40、36、55次/分。首先对症治疗。心动过缓试用烟酰胺800mg加入10％葡萄糖500ml中静点,滴速控制在30滴/分(约3.2mg/分)左右(1.6mg/ml)。3例出现房颤均在滴速(失控情况下)大于55～70滴/分、药液滴入200～350ml后。立即停滴烟酰胺液,心电监护并严密观察,4小时后房颤已自行终止,对此应引起高度注意。通过本组治疗,我们认为将滴速控制在30滴/分左右疗效满意,若增大药量,应循序渐进,并严密观察为宜。
The authors used niacinamide treatment of bradycardia in 10 cases, received a certain effect, but 3 cases induced atrial fibrillation in the course of treatment. 2 females, 1 male, aged 48 to 60 years old, diagnosed as sick sinus syndrome in 2 cases, 1 case of coronary heart disease. Heart rate were 40,36,55 beats / min. First symptomatic treatment. Bradycardia trial of nicotinamide 800mg added 10% glucose 500ml in the static point, drip rate control at 30 drops / min (about 3.2mg / min) (1.6mg / ml). 3 cases of atrial fibrillation were drip rate (uncontrolled circumstances) greater than 55 to 70 drops / min, liquid drops after 200 ~ 350ml. Immediately stop drip nicotinamide, ECG and close observation, 4 hours after the termination of atrial fibrillation, this should be a high degree of attention. Through this group of treatment, we believe that the drip rate control at 30 drops / min or so satisfactory results, if the increase in the dose should be gradual and close observation is appropriate.