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给感染异盘并殖吸虫的大鼠分别口服吡喹酮、阿苯达唑100mg/kg·d×2,24h 后作透射电镜观察。吡喹酮组虫体平滑肌外膜破坏,部分肌纤维断裂,合体细胞与实质细胞核溶解坏死,肠平滑肌水肿,肠上皮解体坏死较突出。阿苯达唑组以平滑肌水肿更为显著,致肌纤维分离,合体细胞与实质细胞内质网扩张,线粒体肿胀,肠上皮肿胀出现气球样大泡。结果提示两药对异盘并殖吸虫虫体均有损害作用,尤以吡喹酮作用更强。
Paragonimus infection in rats were administered praziquantel, respectively, albendazole 100mg / kg · d × 2,24h after transmission electron microscopy. Praziquantel group worm body outer smooth muscle destruction, part of the muscle fiber rupture, somatic cells and parenchymal nucleolysis necrosis, intestinal smooth muscle edema, intestinal epithelial disintegration necrosis more prominent. Albendazole group with more obvious muscle edema, induced muscle fiber separation, somatic cells and parenchymal cells endoplasmic reticulum dilatation, swelling of the mitochondria, intestinal effusion balloon-like bullae appear. The results suggest that the two drugs have a damaging effect on Paragonimus parasporum, especially praziquantel.