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The discovery of penicillin in1929,and cephalosporin in 1956 leadto the development of new semisynthetic β-lactam antibiotics by the acylation of 6-aminopenicillanic acid and 7aminocephalosporanic acid. Success withthese antibiotics, which were of greatclinical value, stimulated the pharmaceutical industry to search for new β-lactam antibiotics,and a variety of newmethodologies were established andapplied to their detection.As a result,many β-lactam antibiotics with novelnuclei were discovered from microbialsources, mainly from actinomycetes and
The discovery of penicillin in1929, and cephalosporin in 1956 lead to the development of new semisynthetic beta-lactam antibiotics by the acylation of 6-aminopenicillanic acid and 7aminocephalosporanic acid. Success with the use of antibiotics, which were of great clinical value, stimulated the pharmaceutical industry to search for new β-lactam antibiotics, and a variety of new methods were established and applied to their detection. As a result, many β-lactam antibiotics with novel nuclei were discovered from microbial sources, mainly from actinomycetes and