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目的探讨健康体检人群中非酒精性脂肪性肝病(NAFLD)患病及相关危险因素,为临床预防及控制提供科学依据。方法采用横断面调查研究方法,以810名健康体检人群为研究对象,收集相关的临床资料进行统计学分析。结果 NAFLD患病142例,总患病率为17.5%,男性98例,患病率为20.9%,女性44例,患病率为12.9%,不同性别间差异有统计学意义(P<0.01);多因素Logistic回归分析结果显示,体质指数、甘油三酯、空腹血糖、舒张压、年龄、谷丙转氨酶、饮食习惯及运动锻炼与NAFLD发病有关(P<0.05)。结论广州市成人NAFLD患病率较高;超重或肥胖,甘油三酯、空腹血糖、舒张压及谷丙转氨酶升高,年龄较大、高脂饮食及缺乏运动锻炼是NAFLD患病的独立危险因素。
Objective To explore the prevalence and risk factors of non-alcoholic fatty liver disease (NAFLD) in health examination population and provide a scientific basis for clinical prevention and control. Methods By means of cross-sectional investigation, 810 healthy people were selected as the research object, and the related clinical data were collected for statistical analysis. Results There were 142 cases with NAFLD, the total prevalence was 17.5%. There were 98 males, the prevalence was 20.9%, the females 44%, the prevalence was 12.9%. The difference was statistically significant (P <0.01) Multivariate Logistic regression analysis showed that body mass index, triglyceride, fasting blood glucose, diastolic blood pressure, age, alanine aminotransferase, diet and exercise were related to the incidence of NAFLD (P <0.05). Conclusions The prevalence of NAFLD is higher in adults in Guangzhou. The overweight or obesity, triglyceride, fasting blood glucose, diastolic blood pressure and elevated alanine aminotransferase, higher age, high fat diet and lack of exercise are independent risk factors for NAFLD .