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自体免疫内分泌病如甲状腺机能亢进、甲状腺机能低下及胰岛素依赖型糖尿病作为α-干扰素的副作用已有报导,但其所致的垂体机能低下尚无报导.一位44岁的妇女患有慢性丙肝,1992年12月,接受重组α_(2b)干扰素10~6(100万单位)治疗,每周3次,共3个月,于治疗2周后主诉全身乏力、水肿、月经不调,但治疗仍持续到3月.1993年4月就诊时见面部和胫骨前部水肿,但无甲状腺肿大,血清游离甲状腺素1.1ng/dL(正常值0.85～2.15),游离三碘甲状腺氨酸2.4pg/dL(2.8～6.0),TSH0.1μu/mL(0.3～3.5),血清可的索和促皮质激素分别为4.0μg/mL(4.4～17.4)和1.2pg/mL(6.1～55.0),其它激素(生长素、黄体素、卵泡刺激素和催乳素)的基础水平正常,血清可的索和促皮质激素对胰岛素诱导的低血糖和赖氨酸-抗利尿激素无应答,但促皮质激素刺激后血清可的索升至26.6μg/mL,显示新近发生促皮质激素缺乏.TSH对TSH释放激素及生长激素有反应,对精氨酸的反应迟钝.
The side effects of autoimmune endocrine diseases such as hyperthyroidism, hypothyroidism and insulin-dependent diabetes mellitus have been reported as side effects of interferon-alpha but no reports of hypopituitarism have been reported yet A 44-year-old woman has chronic hepatitis C , December 1992, received recombinant α 2b interferon 10 to 6 (1 million units) treatment, 3 times a week for a total of 3 months, after 2 weeks of treatment the main complaint of generalized weakness, edema, irregular menstruation, but Treatment continued until March 1993. Seeing the face and tibial anterior edema at the visit in April 1993, but without goiter, serum free thyroxine 1.1ng / dL (normal 0.85 to 2.15), free triiodothyronine 2.4 Serum cordyceps and corticosteroids were 4.0 μg / mL (4.4 ~ 17.4) and 1.2pg / mL (6.1 ~ 55.0), respectively, with pg / dL of 2.8-6.0 and TSH of 0.1-3.5. The basal levels of other hormones (auxin, lutein, follicle-stimulating hormone and prolactin) are normal, and serum cords and corticosteroids have no response to insulin-induced hypoglycemia and lysine-antidiuretic hormone but corticotropin Stimulation of serum can be cable up to 26.6μg / mL, showing the recent corticosteroid deficiency TSH release of TSH and hormone Growth hormone response, unresponsive to arginine.