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目的通过肌肉活检技术,对于肌炎治疗过程中症状加重的临床病例进行诊断性鉴别,从而指导临床治疗。方法选取临床上应用糖皮质激素治疗,病情出现反复,症状进行性加重,通过普通实验室手段鉴别诊断困难的肌炎患者5例,采用肌肉活检技术,组织化学染色,分析病理结果。结果在5例病例中,有2例病理结果有炎性活动病灶,提示肌炎复发;3例病理结果符合类固醇肌病改变,提示激素过量导致类固醇肌病。结论肌活检技术对于鉴别肌炎治疗过程中肌炎复发还是激素过量导致的类固醇肌病具有重要意义。
Objective Through the muscle biopsy technology, for the treatment of myositis in the clinical symptoms of exacerbations in the diagnosis of differential diagnosis, to guide clinical treatment. Methods The clinical application of glucocorticoid treatment, the disease appeared repeatedly, the symptoms aggravated, common laboratory methods in the differential diagnosis of myositis in 5 patients, the use of muscle biopsy, histological staining, pathological results. Results In 5 cases, there were 2 inflammatory lesions in the pathological results, suggesting myositis recurred. The pathological findings of 3 cases were consistent with the changes of steroid myopathy, suggesting that excessive hormones lead to steroid myopathy. Conclusions Muscle biopsy technique is of great significance for the identification of myositis recurrence or steroid myopathy caused by excessive hormones in the treatment of myositis.