Neuroprotective effect of Notch pathway inhibitor DAPT against focal cerebral ischemia/reperfusion 3

• 作 者: Jun-Jie Wang Jun-De Zhu Xian-H
• 机 构: DepartmentofAnatomy
• 出 处: 中国神经再生研究:英文版
• 发表日期: 2019年3期
• 关键词: nerve REGENERATION DAPT cerebral ISCHEMIA GLIAL fibrillary ACIDIC protein Notch1
• 基金项目: the National Natural Science Foundation of China,No.81660243(to JDZ),a grant from the Social Development Science and Technology Plan Project of Science and Technology Department of Guizhou Province of

As an inhibitor of the Notch signaling pathway, N-[N-(3,5-difluorohenacetyl)-l-alanyl]-S-phenylglycine tert-butyl ester(DAPT) may protect brain tissue from serious ischemic injury. This study aimed to explore neuroprotection by DAPT after cerebral ischemi