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为寻找治疗早期宫外孕氨甲蝶呤(MTX)的最佳剂量,即用最小的剂量达到最大的疗效以及最低的毒副作用的目的,我院自1994年12月至1995年12月期间,在115例宫外孕中,对符合本文条件的病例选择37例早期宫外孕用小剂量MTX保守治疗。剂量为lmg·kg ̄(-1).d ̄(-1),共2天,隔日用四氢叶酸0.lmg·kg ̄(-1)·d ̄(-1),共2天。34例治疗成功,成功率为91.98%。无毒副作用发生。和同期手术治疗的输卵管妊娠相比较,节省了十分之一的住院费用。文中对宫外孕早诊的手段,MTX的剂量,血清β-hcG动态随访及阴道“甲超的跟踪探查进行讨论。本文结果提示:用小剂量MTX治疗早期宫外孕是安全的,有效的。
In order to find out the optimal dose of methotrexate (MTX) for early ectopic pregnancy, that is, to achieve the maximal curative effect with the lowest dose and the lowest toxic side effects, in our hospital from December 1994 to December 1995, Cases of ectopic pregnancy, the conditions in line with this article selected 37 cases of early ectopic pregnancy with low-dose MTX conservative treatment. The dose of lmg · kg ~ (-1). d ~ (-1), a total of 2 days, the next day with tetrahydrofolate 0. lmg · kg ~ (-1) · d ~ (-1) for 2 days. 34 cases of successful treatment, the success rate was 91.98%. Non-toxic side effects occur. One-tenth of the cost of hospitalization was saved when compared with the surgical treatment of tubal pregnancy. This paper discusses the means of early diagnosis of ectopic pregnancy, the dose of MTX, the dynamic follow-up of serum β-hcG and the follow-up exploration of vaginal “superfat.” The results suggest that the treatment of early ectopic pregnancy with low-dose MTX is safe and effective.