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目的:探讨血清癌胚抗原(CEA)、细胞角蛋白19片段(CYFRA21-1)、神经元特异性烯醇化酶(NSE)、糖类抗原125(CA125)在肺癌诊治及预后评估中的应用价值。方法:将我院收治的324例肺癌患者(研究组)和58例正常人(对照组)作为研究对象,采集研究对象的血清标本,进行CEA、CYFRA21-1、NES、CA125水平检测,对比检测结果,分析其在肺癌诊断、治疗及预后评估中的应用价值。结果:研究组的CEA、CYFRA21-1、NSE、CA125水平均显著高于对照组,肺癌预后良好患者的CEA、CYFRA21-1、NSE、CA125水平均显著低于预后不良者(P<0.05)。CEA、CYFRA21-1、NSE、CA125及4项联合检测对肺癌的诊断特异性分别为98.15%、95.99%、97.84%、91.98%、89.81%。4项联合检测对肺癌的诊断敏感性为84.26%,显著高于各单项检测(P<0.05)。CEA对腺癌的诊断敏感性显著高于腺癌和小细胞癌,CYFRA21-1对鳞癌的诊断敏感性显著高于腺癌和小细胞癌,NSE对小细胞癌的诊断敏感性显著高于鳞癌和腺癌(P<0.05);4项联合检测对鳞癌、腺癌、小细胞癌的诊断敏感性均显著高于各单项检测(P<0.05)。结论:CEA、CYFRA21-1、NSE、CA125在肺癌的诊断中具有重要价值,联合进行4项肿瘤标志物检测,能够有效提高肺癌诊断准确率,同时为肺癌的治疗及预后评估提供有效依据。
Objective: To investigate the value of serum CEA, CYFRA21-1, NSE and CA125 in diagnosis and prognosis of lung cancer . Methods: A total of 324 lung cancer patients (study group) and 58 normal individuals (control group) admitted to our hospital were enrolled in this study. Serum samples were collected from the patients and CEA, CYFRA21-1, NES and CA125 levels were detected. Results, analysis of its value in diagnosis, treatment and prognosis of lung cancer. Results: The levels of CEA, CYFRA21-1, NSE and CA125 in the study group were significantly higher than those in the control group. The levels of CEA, CYFRA21-1, NSE and CA125 in patients with good prognosis of lung cancer were significantly lower than those with poor prognosis (P <0.05). The diagnostic specificity of CEA, CYFRA21-1, NSE, CA125 and 4 combined tests for lung cancer were 98.15%, 95.99%, 97.84%, 91.98% and 89.81% respectively. The sensitivity of the four combined tests for the diagnosis of lung cancer was 84.26%, significantly higher than that of the individual tests (P <0.05). The diagnostic sensitivity of CEA to adenocarcinoma was significantly higher than that of adenocarcinoma and small cell carcinoma. The diagnostic sensitivity of CYFRA21-1 to squamous cell carcinoma was significantly higher than that of adenocarcinoma and small cell carcinoma. The diagnostic sensitivity of NSE to small cell carcinoma was significantly higher Squamous cell carcinoma and adenocarcinoma (P <0.05). The diagnostic sensitivities of the four combined tests to squamous cell carcinoma, adenocarcinoma and small cell carcinoma were significantly higher than those of single detection (P <0.05). Conclusions: CEA, CYFRA21-1, NSE and CA125 are of great value in the diagnosis of lung cancer. Combined detection of 4 tumor markers can effectively improve the diagnostic accuracy of lung cancer and provide an effective basis for the treatment and prognosis evaluation of lung cancer.