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目的探讨宁夏地区回汉族人群冠心病与血浆中凝血因子Ⅶ的相关性,为冠心病新危险因子的发现提供实验室依据。方法比较宁夏地区回族人群冠心病患者(120例)和健康对照组(80例)间血浆凝血因子活性的差别,FⅦa:采用重组可溶组织因子法,FⅦAg:用ELISA法,FⅦc:用一阶段凝固法。结果回族冠心病凝血因子FⅦa活性2.6±0.5,高于正常对照组2.2±0.7(P<0.005)。汉族冠心病凝血因子FⅦa活性2.5±0.8,高于正常对照组2.2±0.7(P<0.005)。回族冠心病凝血因子FⅦc活性103.04±16.70,高于正常对照组86±22.0(P<0.005)。汉族冠心病凝血因子FⅦc活性102.66±17.33,高于正常对照组87.5±22.0(P<0005)。FⅦ:Ag较稳定,与健康对照组比较差异无统计学意义。结论检测FⅦa、FⅦAg与FⅦc3项凝血因子可以为评估冠心病及其危险事件的发生提供实验室依据,FⅦ活性的增高与冠心病患者动脉血栓形成发病可能有直接相关性。
Objective To investigate the correlation between coronary heart disease and plasma coagulation factor Ⅶ in Han and Han nationality in Ningxia and to provide a laboratory basis for the discovery of new risk factors of coronary heart disease. Methods The differences of plasma coagulation factor activities between CHD patients (n = 120) and healthy controls (n = 80) in Ningxia were compared. FⅦa: Recombinant soluble tissue factor method, FⅦAg: ELISA, FⅦc: Solidification method. Results The FⅦa activity of CHD was 2.6 ± 0.5, which was higher than that of the control group (2.2 ± 0.7) (P <0.005). The activity of coagulation factor FⅦa in Han nationality was 2.5 ± 0.8, higher than that of the normal control group (2.2 ± 0.7) (P <0.005). The activity of coagulation factor FⅦc in Hui ethnic group was 103.04 ± 16.70, which was higher than that of the normal control group (86 ± 22.0, P <0.005). Han Chinese CHD FⅦc activity 102.66 ± 17.33, higher than the control group 87.5 ± 22.0 (P <0005). FⅦ: Ag is more stable than the healthy control group, with no significant difference. Conclusion Detecting FⅦa, FⅦAg and FⅦc coagulation factors may provide a laboratory basis for assessing the occurrence of coronary heart disease and its dangerous events. The increase of FⅦ activity may be directly related to the pathogenesis of arterial thrombosis in patients with coronary heart disease.