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本文以氰基丙烯酸正丁酯（ＢＣＡ）为囊材制备了阿克拉霉素Ａ毫微囊（ＡＣＭ－Ａ－ＮＣ），利用均匀设计方案选出了较佳处方，加冻干赋型剂制得了阿克拉霉素Ａ毫微囊冻干品，冻干前后的平均粒经分别为（１２０±３４）ｎｍ和（１４６±３３）ｎｍ，应用凝胶过滤色谱法得阿克拉霉素Ａ的包封率为４７．６％，并进行了ＡＣＭ－Ａ－ＮＣ的ＬＤ５０测定以及对Ｓ１８０肉瘤，Ｐ３８８白血病的抑瘤实验，结果表明，ＡＣＮ－Ａ－ＮＣ降低了ＡＣＭ－Ａ的毒性，其抗癌活性也有所改善。
In this paper, acylaminomycin A nanocapsules (ACM-A-NC) were prepared by using n-butyl cyanoacrylate (BCA) as the encapsulating material. The optimal formulation was selected by uniform design. The results showed that the average particle size of the aflatoxin A nanocapsules before and after lyophilization was (120 ± 34) nm and (146 ± 33) nm, respectively, and the inclusion of aclacinomycin A by gel filtration chromatography The antitumor activity of ACM-A-NC was 47.6%. LD50 of ACM-A-NC and anti-tumor activity of S180 sarcoma and P388 leukemia were also tested. The results showed that ACN-A-NC reduced the toxicity of ACM- Activity has also improved.