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目的探讨应用不同疗程5％咪喹莫特乳膏预防尖锐湿疣复发的疗效和安全性。方法采用随机、对照的方法,将患者分成3组：A组单用CO_2激光治疗：B组用CO_2激光祛除疣体后外用5％咪喹莫特乳膏4周,每周3次；C组用CO_2激光祛除疣体后外用5％咪喹莫特乳膏8周,每周3次。所有患者均随访6个月。结果共有90例外生殖器及肛周尖锐湿疣患者完成临床研究,6个月后,3组的复发率分别为64．29％、50％及21．88％,3组复发率比较,差异有统计学意义(P=0．0033)。外用咪喹莫特乳膏8周组复发率低于前两组；外用4周组与8周组复发率比较,差异有统计学意义(P=0．0207)。激光治疗后外用5％咪喹莫特乳膏4周组与8周组出现的不良反应率分别为73．33％,84．38％。不良反应包括：红斑、瘙痒、疼痛、灼热、糜烂、溃疡,以及流感样症状,两组差异无统计学意义(P＞0．05)。结论激光治疗后外用5％咪喹莫特乳膏8周,皮损的复发率比外用4周明显下降。两组安全性无明显差异。
Objective To investigate the efficacy and safety of applying 5% imiquimod cream in different courses to prevent recurrence of condyloma acuminatum. Methods The patients were divided into 3 groups by a randomized and controlled method: group A was treated with CO 2 laser alone: group B was treated with CO 2 laser and the topical 5% imiquimod cream was applied for 4 weeks, three times a week; group C Quench the body with CO_2 laser topical 5% imiquimod cream for 8 weeks, 3 times a week. All patients were followed up for 6 months. Results A total of 90 patients with genital and perianal genital warts completed clinical studies. After 6 months, the recurrence rates of the three groups were 64.29%, 50% and 21.88% respectively. The recurrence rates of the three groups were statistically different Significance (P = 0.0033). The recurrence rate of topical imiquimod cream in 8-week group was lower than that of the former two groups. The recurrence rate of topical imiquimod cream in 8-week group was lower than that of the former two groups (P = 0.0207). The adverse reaction rates of topical 5% imiquimod cream 4 weeks and 8 weeks after laser treatment were 73.33% and 84.38% respectively. Adverse reactions included erythema, pruritus, pain, burning, erosion, ulcer, and flu-like symptoms, with no significant difference between the two groups (P> 0.05). Conclusion After 5 weeks of laser treatment, topical imiquimod cream was applied for 8 weeks. The recurrence rate of the lesion was significantly lower than that of the external application for 4 weeks. No significant difference in safety between the two groups.