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左心疾病相关肺动脉高压(PAH)是肺循环压力升高最常见的原因,PAH是左心疾病发展到后期的常见并发症,可出现在任何左心系统疾病所引起的心力衰竭中。一旦出现PAH和右心功能不全,患者的临床症状和运动耐量将明显恶化,预后较差。然而,目前国内外关于左心力衰竭相关PAH的研究较少,其流行病学、病理生理机制、基础治疗及PAH靶向药物治疗方面尚缺乏有效的数据。文章将对左心疾病相关PAH的流行病学、临床评估、治疗、最新证据及预后评估方面的最新文献进行综述。
Pulmonary hypertension (PAH) associated with left heart disease is the most common cause of elevated pulmonary circulation pressure. PAH is a common complication of the development of left heart disease to the late stage and can occur in any heart failure caused by left heart disease. In the event of PAH and right ventricular dysfunction, the patient’s clinical symptoms and exercise tolerance will be significantly worse, the prognosis is poor. However, there are few researches on PAH related to left heart failure at home and abroad, and there is still no valid data about its epidemiology, pathophysiological mechanism, basic treatment and PAH-targeted drug therapy. This article reviews recent literature on the epidemiology, clinical evaluation, treatment, recent evidence, and prognostic assessments of PAH associated with left heart disease.