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Naproxen钠(Anaprox)是一种血小板聚集及前列腺素合成的强力抑制剂,也是一种强力消炎、止痛剂,新近报导对预防偏头痛有效。作者用双盲法、随机、安慰剂对照治疗普通或典型偏头痛患者40例。Anaprox剂量为550mg 2/日,全程20周,第1～2周及第11～12周行单盲法安慰剂治疗,首先接受Anaprox或安慰剂的两组病例特点无明显差别。观察期间不用其他对抗血小板聚集和前列腺素合成有抑制作用的一切药物。40例中34例完成了全部疗程,其他6例中途停药。疗效由病人检查者分别记录并评定优、良、中、差,依次记4、3、2、1分;每8周医
Naproxen Sodium (Anaprox) is a potent inhibitor of platelet aggregation and prostaglandin synthesis, but also a potent anti-inflammatory and analgesic agent, recently reported to be effective in preventing migraines. The authors used a double-blind, randomized, placebo-controlled trial of 40 patients with common or typical migraine. Anaprox dose 550mg 2 / day, the entire 20 weeks, 1 to 2 weeks and 11 to 12 weeks of a single-blind placebo treatment, first received Anaprox or placebo in the characteristics of the two groups no significant difference. During the observation period without any other anti-platelet aggregation and prostaglandin synthesis inhibition of all drugs. Of the 40 patients, 34 completed the full course of treatment and the other 6 discontinued halfway. The curative effect was recorded and evaluated respectively by the patient’s examiner for excellence, goodness, goodness, badness, followed by 4,3,2,1 points; every 8 weeks