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本文用Ames检测方法,研究了β-胡罗卜素、维生素C、羟乙基倍半锗氧化物和亚硒酸钠对直接诱变剂甲基硝基亚硝基胍(MNNG)诱发TA_(100)菌株回复突变作用的抑制效果。四种阻断剂均有较明显的抗诱变作用(抑制率达60%以上)并呈一定的剂量效应关系,测定其ED_(50)值,并比较了它们的抑制效果,当四种阻断剂小同组合时,二种阻断剂同时作用其抑制率均比单独使用时高,抑制率可达85%,说明各种阻断刺之间有协同作用。
In this paper, Ames test method was used to study the effects of β-carotene, vitamin C, hydroxyethyl-sesqui-germanium oxide and sodium selenite on the induction of TA_ (2) by the direct mutagen methyl nitrosoguanidine (MNNG) 100) strains of the bacteriostatic effect of the mutation. The four kinds of blockers had obvious anti-mutagenic effect (the inhibition rate was over 60%) and had a dose-dependent relationship. The ED50 values of the four kinds of blockers were measured and their inhibitory effects were compared. The same combination of agents, the two inhibitors at the same time the inhibition rate were higher than when alone, the inhibition rate of up to 85%, indicating a synergy between the various blocking barbed.