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目的：：探讨慢性阻塞性肺疾病( COPD)合并肺源性心脏病危险相关因素。方法：选取50例慢性阻塞性肺疾病合并肺源性心脏病住院患者作为研究组，同时选取同期COPD未合并肺源性心脏病住院患者作为对照组，分析COPD患者发生肺心病的危险因素。结果：研究组患者在PaO2、 PaCO2、 CD4+/CD8+、 FEV1及FEV1/FVC方面均差于对照组，差异有统计学意义(P<0．05)。疾病加重次数、吸烟指数及SGRQ评分是慢性阻塞性肺疾病合并肺源性心脏病的危险因素。结论：稳定患者病情，减少COPD急性发作次数，戒烟，及时疏导患者负性心理有利于降低慢性阻塞性肺疾病合并肺源性心脏病的危险性，提高患者生活质量，改善预后。“,”OBJECTIVE: To analyse the risk factors in chronic obstructive pulmonary disease ( COPD) combined with cor pul-monale. METHODS: 50 hospitalized patients with COPD combined with cor pulmonale were as the study group and oither hospitalized patients only with COPD during the same period were as the control group. The risk factors of cor pulmonale in the patients with COPD were analysed. RESULTS: The levels of PaO2 , PaCO2 , CD4 + /CD8 +, FEV1 and FEV1/FVC were lower in the studly group than those in the control group. There was statistically significant difference (P<0. 05). Degree of diseases, smoking index and SGRQ scores were the risk factors of COPD combined with cor pulmonale. CONCLUSION: To stabilize the disease, decrease the times of the onset of COPD and give up smoking can decrease the risk of COPD combined with cor pulmonale. And the methods above may also im-prove the quality of life and the prognosis of the patients.