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Objective: To investigate the expression of p120ctn in non-small-cell lung cancer (NSCLC) and its relationshipwith clinicopathological factors and prognosis. Methods: p120ctn expression was tested by immunohistochemistryfor 80 tumors from patients with non-small-cell lung cancer. Correlations were investigated between p120ctnimmunostaining in primary tumors and clinicopathological characteristics and survival. Results: Abnormal expression of p120ctn was found in 68/80(85%) tumors in which 43cases had cytoplasmic staining. Abnormal staining ofp120ctn was related with high TNM stage (P=0.003) andnodal metastasis (P=0.024). However, there was nocorrelation between altered expression with poordifferentiation and histological type. According toKaplan-Meier survival estimate, the expression of p120ctn was related to the poor survival (P=0.015) of patients. ACox regression analysis revealed that p120ctn expressiowas a significant independent factor in the prediction ofsurvival for patients with non-small-cell lung cancer(P=0.008). Conclusion: altered expression of p120ctn wasfound in non-small-cell lung cancers and was correlated with lymph node metastasis and prognosis. From a practical point of view, the expression of p120ctn can be of prognostic value for patients with non-small-cell lung cancer.
Objective: To investigate the expression of p120ctn in non-small-cell lung cancer (NSCLC) and its relationship with clinicopathological factors and prognosis. Methods: p120ctn expression was tested by immunohistochemistry for 80 tumors from patients with non-small-cell lung cancer. Correlations were Abnormal staining of p120ctn was related to high TNM stage (P = 0.003) was observed in p120ctnimmunostaining in primary tumors and clinicopathological characteristics and survival. Results: Abnormal expression of p120ctn was found in 68/80 (85%) tumors in which 43cases had cytoplasmic staining. According to Kaplan-Meier survival estimate, the expression of p120ctn was related to the poor survival (P = 0.015) of patients. ACox regression analysis revealed that p120ctn expressiowas a significant independent factor in the prediction ofs vulvival for patients wi Conclusion: altered expression of p120ctn was found in non-small-cell lung cancers and was associated with lymph node metastasis and prognosis. From a practical point of view, the expression of p120ctn can be of prognostic value for patients with non-small-cell lung cancer.