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患者在服药期间同时饮酒致使药物疗效改变或产生用药事故,医务工作者和病人家属应引起足够的重视。本文就易与酒或醇性饮料相互作用的几种药物作如下分析,以提示临床用药的注意。 1 氨甲喋呤(MTX) MTX可抑制肿瘤细胞的增殖,但对正常组织也有损害,用药量较大时可致肝毒性。而嗜酒者约15％～20％会发生酒精性肝炎,损害肝脏。所以饮酒时再使用本药物可加重肝损害,甚而引起肝昏迷和呼吸抑制。
Patients during the medication while drinking alcohol resulting in changes in the efficacy of drugs or resulting in medication accidents, medical workers and their families should be given enough attention. In this paper, several drugs that are easy to interact with alcohol or alcoholic beverages are analyzed as follows to show the attention of clinical medication. Methotrexate (MTX) MTX can inhibit the proliferation of tumor cells, but also damage the normal tissue, the larger the dose can cause liver toxicity. About 15% to 20% of alcoholics will develop alcoholic hepatitis and damage the liver. So drinking alcohol and then use this drug can aggravate liver damage, even causing hepatic coma and respiratory depression.