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目的 :研究传染性非典型肺炎患者特异性体液免疫与其病情的关系。方法 :采用间接酶联免疫法和双抗原夹心法检测不同病情SARS患者血清中特异性抗体。结果 :间接法重症组SARS患者IgG的效价比轻症组高 2 9倍 ,IgM的效价比轻症组高 1 7倍 ;双抗原夹心法重症组SARS患者特异性抗体的效价比轻症组高 2 6倍。可见两种血清学方法的检测结果均是重症组血清特异性抗体的效价显著高于轻症组 ;间接法重症组SARS患者IgG的阳性检出率比轻症组高 5 8 2 % ,IgM高2 2 1% ;双抗原夹心法重症组SARS患者特异性抗体阳性检出率比轻症组高 5 3 9%。结论 :SARS重症组血清特异性抗体效价显著高于轻症组 ;重症组血清特异性抗体阳性检出率显著高于轻症组。
Objective: To study the relationship between specific humoral immunity and its condition in patients with SARS. Methods: Serum specific antibodies in SARS patients with different disease conditions were detected by indirect enzyme - linked immunosorbent assay and double antigen sandwich method. Results: The titer of IgG in SARS patients was 29 times higher than that in mild cases and the titer of IgM was 17 times higher than that of mild cases in severe SARS patients. The specific antibody titer of SARS patients in SARS patients was significantly lower than that of mild cases Syndrome group 26 times higher. The results of two serological methods showed that the titer of serum specific antibody in severe group was significantly higher than that of mild group. The positive rate of IgG in SARS patients was 58.2% High 2 121%; double antigen sandwich severe SARS patients with specific antibody positive detection rate of 539% higher than the mild group. Conclusion: The titer of serum specific antibody in patients with severe acute respiratory syndrome was significantly higher than that of mild patients. The positive rate of serum specific antibodies in severe patients was significantly higher than that of mild patients.