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本文为一开放的前瞻性研究。按照预先设计的随机表,将所有不同年龄和性别并具有急性细菌性脑膜炎症状和体征的患者在非选择性交替的基础上分为两组:Ⅰ组采用地塞米松、氨苄青霉素和氯霉素治疗;Ⅱ组仅用氨苄青霉素和氯霉素治疗。氨苄青霉素每日160mg/Kg和氯霉素每日100mg/kg,分4次肌注。Ⅰ组患者并用地塞米松,年龄<12岁者8mg,成人12mg,每12小时1次,共3天。除Ⅰ组10例和Ⅱ组15例因发烧或脑脊液检查异常而延长疗程2～3天外,均在治疗后8天停用抗生素。结果:470例患者中脑脊液分离或涂片找到病原菌者429例,其中男278例,女151例,
This article is an open-ended, prospective study. All patients of different ages and genders with acute bacterial meningitis symptoms and signs were divided into two groups on a non-selective alternation according to a pre-designed randomized table: Group I was treated with dexamethasone, ampicillin and chloramphenicol The treatment group Ⅱ only ampicillin and chloramphenicol treatment. Ampicillin daily 160mg / Kg and chloramphenicol daily 100mg / kg, 4 times intramuscular injection. Patients in group Ⅰ were treated with dexamethasone, 8 mg, aged 12 years and 12 mg in adults, once every 12 hours for 3 days. In addition to group Ⅰ 10 and group Ⅱ 15 patients due to fever or cerebrospinal fluid abnormalities and extended treatment of 2 to 3 days, were disabled 8 days after treatment of antibiotics. Results: Among 470 patients, 429 cases of pathogen were found in cerebrospinal fluid separation or smear, including 278 males and 151 females,