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基于1,4-二叠氮双环[2.2.2]辛烷(DABCO)的新型羟基功能化离子液体作为催化剂在无溶剂条件下催化苯甲醛与氰基乙酸乙酯或2,4-噻唑烷二酮的Knoevenagel缩合反应,在温和反应条件下,可以较高产率分别得到β-苯基-α氰基丙烯酸乙酯(≥99%)和5-苯乙烯基-2,4-噻唑烷二酮(92%).这些催化反应操作简单,产物可从反应混合物中直接分离得到,并且催化剂表现出较好的重复利用率.文章最后提出一个可能的反应机理,并进行了相关讨论.
A novel hydroxyl-functional ionic liquid based on 1,4-diazabicyclo [2.2.2] octane (DABCO) was used as a catalyst to catalyze the reaction of benzaldehyde with ethyl cyanoacetate or 2,4-thiazolidine in a solvent- Ketone Knoevenagel condensation reaction, under mild reaction conditions, can be obtained in higher yields β-phenyl-α cyanoethyl acrylate (≥ 99%) and 5-styryl-2,4-thiazolidinedione ( 92%.) These catalytic reactions are simple, the products can be directly separated from the reaction mixture, and the catalyst showed good recycle rate.A possible reaction mechanism was proposed and discussed in the end.