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治疗高血压病中,不同机制降压药纵然获得等同的降压作用,对预后的影响可截然相异。因为不同降压药有不同的血液动力学和内分泌效应。为此,降压药的血液动力学作用颇有研究必要。以往,由于受到创伤性检查方法的限制,临床研究都局限于急性试验,短期或长期高血压治疗的血液动力学及左室功能参数的资料也很有限,尤其在相似病情病人中不同降压药作用的比较报道,更是罕见。目前,已可应用超声心动图连续观察降压药的短期或长期效应,方便了临床药理学的研究。最近,我们在临床上证实2种新型降压药:即有心脏选择性的β-肾上腺素能
In the treatment of hypertension, different mechanisms of antihypertensive drugs even if the equivalent antihypertensive effect on the prognosis may be completely different. Because different antihypertensive drugs have different hemodynamic and endocrine effects. To this end, antihypertensive drugs hemodynamic role quite necessary research. In the past, due to the limitations of traumatic examination methods, clinical studies are limited to acute trials, short-term or long-term hypertension and hemodynamic parameters of left ventricular function is limited, especially in similar disease patients with different antihypertensive drugs The role of comparison reports, it is even rare. At present, echocardiography has been applied continuously to observe the short-term or long-term effects of antihypertensive drugs, facilitating clinical pharmacology research. Recently, we have clinically proven two new types of antihypertensive drugs: the cardioselective β-adrenergic