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【目的】探讨精索静脉曲张对弱精症不育患者睾丸及精液指标的影响。【方法】收集110例弱精症伴精索静脉曲张患者(观察组),根据临床型精索静脉曲张分级:Ⅰ级37例,Ⅱ级39例,Ⅲ级34例;另外选取35例健康男性志愿者为对照组,两组均进行睾丸、附睾、精索静脉最大内径及精索静脉反流情况检查。比较各组间睾丸体积、精液质量。【结果】观察组分级患者的精子活力、精子活率及精子浓度均明显低于对照组( P <0.05),且随着曲张程度的增加,精子活力、精子活率及精子浓度依次降低(P 0.05);观察组左侧、右侧睾丸体积均小于对照组(P <0.05);观察组分级患者左侧睾丸体积均明显小于右侧(P <0.05),且随着曲张程度的增加双侧睾丸体积依次减小(P <0.05)。【结论】不同程度的精索静脉曲张可引起睾丸体积减小,精液质量下降,随曲张程度增加,睾丸体积变小越明显、精液质量也呈下降趋势。“,”Objective]To investigate the influence of the varicocele on testis and semen parameters of in-fertile patients with weak sperm.[Methods]1 10 cases of patients with asthenospermia with varicocele (obser-vation group)were chosen and classified according to the type of clinical varicocele as GradeⅠ of 37 cases, GradeⅡ of 39 cases and GradeⅢ of 34 cases .In addition,35 healthy male volunteers were selected as control group.The two groups were examined with the maximum diameter of the testis,epididymis ,the maximum internal diameter of spermatic vein and varicocele regurgitation.The testicular volume and semen quality were compared among the groups.[Results]The sperm motility,sperm motility rate and sperm concentrations of the classified patients of the observation group were significantly lower than those of the control group (P <0.05)and as the degree of varices increased,sperm motility,sperm motility rate and sperm concentration de-creased (P 0.05);The left and right testis volume of the classified patients in the observation group were significantly less than that in control group (P <0.05 );and the left testicular volume of the classified patients in the observation group were significantly less than that on the right side (P < 0.05 )and the bilateral testicular volume de-creased with the degree of varices increased (P <0.05).[Conclusion]Different degrees of varicocele can lead to decrease of testicular volume and the decrease of the quality of the semen.As varicose degree increases,tes-ticular volume becomes smaller,and semen quality is declining significantly.